function numerics()
{
key = String.fromCharCode(window.event.keyCode);
if (!(key >= '0' && key <= '9')) window.event.keyCode=0;
}
<asp:TextBox ID="txt1" Text="" runat="server" onkeypress=" return numerics();"></asp:TextBox>
function isAlpha(keyCode)
{
return ((keyCode >= 65 && keyCode <= 90) || keyCode == 8||keyCode==37||keyCode==39||keyCode==9||keyCode==46)
}
function isNum(keyCode)
{
return((keyCode < 105 && keyCode > 96)||(keyCode < 57 && keyCode > 48) || keyCode == 8||keyCode==37||keyCode==39||keyCode==9||keyCode==46)
}
<asp:TextBox ID="txtUserName" runat="server" onkeydown = "return isAlpha(event.keyCode);" onpaste = "return false;" Width="130px"></asp:TextBox>
public static bool IsNumeric(String strVal)
{
Regex reg = new Regex("[^0-9-]");
Regex reg2 = new Regex("^-[0-9]+$|^[0-9]+$");
return (!reg.IsMatch(strVal) && reg2.IsMatch(strVal));
}